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Intravenous Magnesium in Arterial Disease

S. E. Browne

The coronary collateral circulation has immense potential for the prevention and treatment of coronary heart disease as has collateral circulation in other forms of arterial disease. It is idle to speculate about the state of the coronary collateral circulation in for example Stone Age Man but tragically in modern man it is usually closed and inactive and of no assistance in myocardial infarction or angina. Haddy has shown that the higher the concentration of magnesium infused into dog's arteries the greater the resulting vasodilatation.

Rapid intravenous bolus doses of 8 to 12 mmols of magnesium have been shown to instantaneously and effectively dilate the coronary collateral circulation proving a dramatically effective treatment of acute myocardial infarction, angina and congestive heart failure. For example a man of 44 had a severe myocardial infarction with subsequent crippling angina and a ventricular aneurysm. After 6 rapid intravenous injections of 8 mmols of magnesium he was completely free from angina and enjoyed life for a further 17 years. His coronary arteriogram showed a completely blocked left anterior descending artery but the distal portion was well filled by collateral circulation from the right coronary artery. Out of 126 patients with angina 116 patients had either complete or marked relief of pain after intravenous magnesium. Out of 59 patients with acute myocardial infarction 26 had immediate relief of pain after 8 mmols of magnesium had been given and all 59 recovered without any evidence of arrhythmias. Of 30 patients with cardiac congestive failure 24 were markedly improved.

Opening collateral circulation in the brain is also effective. In non-haemorrhagic cerebral arterial disease intravenous magnesium has secured complete relief of paralysis in 18 out of 35 patients. It has also proved effective in claudication, gangrene, chronic leg ulceration, chilblains, and early renal disease.

Its preventive use in early middle age would improve life expectancy considerably, as it would minimise the impact of subsequent arterial disease or prevent tissue damage completely.

Ref. Browne SE. The case for intravenous magnesium treatment of arterial disease in general practice. Review of 34 years of experience. Journal of Nutritional Medicine (1994) 4, 169-177.

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